diff --git a/srcpkgs/mod_wsgi/patches/cross-python.patch b/srcpkgs/mod_wsgi/patches/cross-python.patch
new file mode 100644
index 00000000000..2821c1c4656
--- /dev/null
+++ b/srcpkgs/mod_wsgi/patches/cross-python.patch
@@ -0,0 +1,107 @@
+diff --git configure.ac configure.ac
+index 63d1bbc..543ecc0 100644
+--- configure.ac
++++ configure.ac
+@@ -100,26 +100,25 @@ fi
+ 
+ AC_SUBST(PYTHON)
+ 
+-PYTHON_VERSION=`${PYTHON} -c 'from sys import stdout; \
++if test x"${PYTHON_VERSION}" = x""; then
++  PYTHON_VERSION=`${PYTHON} -c 'from sys import stdout; \
+     from distutils import sysconfig; \
+     stdout.write(sysconfig.get_config_var("VERSION"))'`
++fi
+ 
+-PYTHON_LDVERSION=`${PYTHON} -c 'from sys import stdout; \
++if test x"${PYTHON_LDVERSION}" = x""; then
++  PYTHON_LDVERSION=`${PYTHON} -c 'from sys import stdout; \
+     from distutils import sysconfig; \
+     stdout.write(sysconfig.get_config_var("LDVERSION") or "")'`
++fi
+ 
+ if test x"${PYTHON_LDVERSION}" = x""; then
+     PYTHON_LDVERSION=${PYTHON_VERSION}
+ fi
+ 
+-CPPFLAGS1=`${PYTHON} -c 'from sys import stdout; \
+-    from distutils import sysconfig; \
+-    stdout.write("-I" + sysconfig.get_config_var("INCLUDEPY"))'`
++CPPFLAGS1=$($PYTHON-config --includes)
+ 
+-CPPFLAGS2=`${PYTHON} -c 'from sys import stdout; \
+-    from distutils import sysconfig; \
+-    stdout.write(" ".join(filter(lambda x: x.startswith("-D"), \
+-    sysconfig.get_config_var("CFLAGS").split())))'`
++CPPFLAGS2=$($PYTHON-config --cflags | tr ' \t' '\n\n' | grep '^-D' | tr '\n' ' ')
+ 
+ if test "${ENABLE_EMBEDDED}" != "yes"; then
+ CPPFLAGS3="-DMOD_WSGI_DISABLE_EMBEDDED"
+@@ -131,66 +130,7 @@ CPPFLAGS="${CPPFLAGS} ${CPPFLAGS1} ${CPPFLAGS2} ${CPPFLAGS3}"
+ 
+ AC_SUBST(CPPFLAGS)
+ 
+-PYTHONLIBDIR=`${PYTHON} -c 'from sys import stdout; \
+-    from distutils import sysconfig; \
+-    stdout.write(sysconfig.get_config_var("LIBDIR"))'`
+-PYTHONCFGDIR=`${PYTHON} -c 'from sys import stdout; \
+-    import distutils.sysconfig; \
+-    stdout.write(distutils.sysconfig.get_python_lib(plat_specific=1, \
+-    standard_lib=1) +"/config")'`
+-PYTHONFRAMEWORKDIR=`${PYTHON} -c 'from sys import stdout; \
+-    from distutils import sysconfig; \
+-    stdout.write(sysconfig.get_config_var("PYTHONFRAMEWORKDIR"))'`
+-PYTHONFRAMEWORKPREFIX=`${PYTHON} -c 'from sys import stdout; \
+-    from distutils import sysconfig; \
+-    stdout.write(sysconfig.get_config_var("PYTHONFRAMEWORKPREFIX"))'`
+-PYTHONFRAMEWORK=`${PYTHON} -c 'from sys import stdout; \
+-    from distutils import sysconfig; \
+-    stdout.write(sysconfig.get_config_var("PYTHONFRAMEWORK"))'`
+-
+-if test "${PYTHON_LDVERSION}" != "${PYTHON_VERSION}"; then
+-    PYTHONCFGDIR="${PYTHONCFGDIR}-${PYTHON_LDVERSION}"
+-fi
+-
+-if test "${PYTHONFRAMEWORKDIR}" = "no-framework" -o \
+-        "${ENABLE_FRAMEWORK}" != "yes"; then
+-    LDFLAGS1="-L${PYTHONLIBDIR}"
+-    LDFLAGS2="-L${PYTHONCFGDIR}"
+-
+-    LDLIBS1="-lpython${PYTHON_LDVERSION}"
+-
+-    # MacOS X seems to be broken and doesn't use ABIFLAGS suffix
+-    # so add a check to try and work out what we need to do.
+-
+-    if test -f "${PYTHONLIBDIR}/libpython${PYTHON_VERSION}.a"; then
+-        LDLIBS1="-lpython${PYTHON_VERSION}"
+-    fi
+-
+-    if test -f "${PYTHONCFGDIR}/libpython${PYTHON_VERSION}.a"; then
+-        LDLIBS1="-lpython${PYTHON_VERSION}"
+-    fi
+-
+-    LDLIBS2=`${PYTHON} -c 'from sys import stdout; \
+-        from distutils import sysconfig; \
+-        stdout.write(sysconfig.get_config_var("LIBS"))'`
+-    LDLIBS3=`${PYTHON} -c 'from sys import stdout; \
+-        from distutils import sysconfig; \
+-        stdout.write(sysconfig.get_config_var("SYSLIBS"))'`
+-else
+-    LDFLAGS1="-Wl,-F${PYTHONFRAMEWORKPREFIX} -framework ${PYTHONFRAMEWORK}"
+-
+-    VERSION="${PYTHON_VERSION}"
+-    STRING="${PYTHONFRAMEWORKDIR}/Versions/${VERSION}/${PYTHONFRAMEWORK}"
+-    LDFLAGS2=`${PYTHON} -c "from sys import stdout; \
+-        from distutils import sysconfig; \
+-        stdout.write(sysconfig.get_config_var(
+-        \"LINKFORSHARED\").replace(\"${STRING}\", ''))" | \
+-        sed -e 's/-Wl,-stack_size,[[0-9]]*//'`
+-
+-    LDLIBS1=`${PYTHON} -c 'from sys import stdout; \
+-        from distutils import sysconfig; \
+-        stdout.write(sysconfig.get_config_var("LIBS"))'`
+-fi
++PYTHONLIBDIR=$($PYTHON-config --ldflags)
+ 
+ CFLAGS1=""
+ for arg in ${CFLAGS}
diff --git a/srcpkgs/mod_wsgi/template b/srcpkgs/mod_wsgi/template
index 21b9f940fac..1d9eae05630 100644
--- a/srcpkgs/mod_wsgi/template
+++ b/srcpkgs/mod_wsgi/template
@@ -3,8 +3,8 @@ pkgname=mod_wsgi
 version=4.6.5
 revision=2
 build_style=gnu-configure
-hostmakedepends="python"
-makedepends="apache-devel python-devel"
+hostmakedepends="python perl automake libtool"
+makedepends="apache-devel python-devel apr-devel"
 short_desc="Python WSGI adapter module for Apache"
 maintainer="Orphaned <orphan@voidlinux.org>"
 license="Apache-2.0"
@@ -13,4 +13,28 @@ changelog="https://modwsgi.readthedocs.io/en/latest/release-notes/version-${vers
 distfiles="https://github.com/GrahamDumpleton/${pkgname}/archive/${version}.tar.gz"
 checksum=5cbe05f8b9b21a9e40d5d7226f4976643b1ee5e23a2d114bceae34d9948be5e0
 lib32disabled=yes
-nocross=yes
+
+pre_configure() {
+	if [ "$CROSS_BUILD" ]; then
+		cp -a ${XBPS_CROSS_BASE}/usr/bin/apxs ${wrksrc}
+		cp -a ${XBPS_CROSS_BASE}/usr/share/apache/webroot/build/config_vars.mk ${wrksrc}
+
+		# Use the modified apxs
+		configure_args+=" --with-apxs=${wrksrc}/apxs"
+		configure_args+=" --with-python=$XBPS_WRAPPERDIR/python"
+		configure_args+=" PYTHON_VERSION=2.7 PYTHON_LDVERSION=2.7"
+
+		# Use the ${wrksrc}/config_vars.mk
+		vsed -i apxs \
+			-e "/config_vars[.]mk/s;[$]installbuilddir;${wrksrc};g" \
+			-e "s;[$]installbuilddir/instdso[.]sh;$XBPS_CROSS_BASE/&;g" \
+
+		# Use apr-1-config and apu-1-config wrappers
+		vsed -i config_vars.mk \
+			-e "/^APR_CONFIG/ s;=.*;= ${XBPS_WRAPPERDIR}/apr-1-config;" \
+			-e "/^APU_CONFIG/ s;=.*;= ${XBPS_WRAPPERDIR}/apu-1-config;" \
+			-e "/^includedir/ s;=.*;= $XBPS_CROSS_BASE/usr/include/httpd;" \
+			-e "s;\([I 	]\)/usr/include;\1$XBPS_CROSS_BASE/usr/include;g"
+	fi
+	autoreconf -fi
+}